Rontgene Solante, MD

Current Positions and Designations 2023: San Lazaro Hospital Chairman of the Adult Infectious Diseases and Tropical Medicine (AIDTM) Fellowship Program of San Lazaro Hospital (a PSMID accredited program in Infectious Disease Fellowship) Chairman, Adult Infectious Diseases and Tropical Medicine Department ManilaMed Medical Center Manila Attending Physician in Infectious Diseases , Department of Medicine Chairman, Infection Prevention and Control Committee Chairman, Antimicrobial Stewardship Program Covid-19 Task Force Head , 2020 up to present Adventist Medical Center Manila Chairman, Section of Infectious Diseases Chairman, Antimicrobial Stewardship Committee Attending Physician in Infectious Diseases, Department of Medicine Covid-19 Task Force Chair 2020- up to present University of the East Ramon Magsaysay Memorial Medical Center (UERMMMC) Clinical Assistant Professor 1, Department of Medicine , College of Medicine Chairman, Section of Infectious Diseases Attending Physician in Infectious Diseases, Department of Medicine Department of Science and Technology (DOST) Vaccine Experts Panel Covid-19 Vaccine 2019-2023 Philippine College of Physicians (PCP) 2023-24 National President, 2023-2024 Steering Committee member 2028 World Congress in Internal Medicine , Manila Philippines Over-all Chair , 53rd PCP Annual Congress and 70th anniversary Philippine Society for Microbiology and Infectious Diseases (PSMID): Past President 2010-2012 Chairman, Standing Committee on Constitution and By-Laws Chairman, Ways and Means PSMID Annual Convention ,2012 until present Member, Council of Advisers and Past Presidents Philippine Foundation for Vaccination (PFV) Board member 2022-2024 Asian Vaccine Conference (ASVAC) Over-all Organizing Committee chair , Nov 7-11, 2023 , launched date March 6, 2023 – advocacy program targeting LGUs to increase influenza prevention thru vaccination RAISE Coalition Lead Convenor (Raising Awareness on Influenza to Support the Elderlies ) Phil FDA, member External pool of experts for the evaluation of COVID vaccine and therapeutics, 2021- up to present Department of Health (DOH), member Strategic Advisory Group of Experts (SAGE) Emerging Re-emerging and Infectious Diseases – June 2022 up to present Department of Health (DOH) Chair, Technical Working group (TWG) Philippine Framework for Hospital Facility Development Program in Infectious Diseases 2019 up to present Department of Health (DOH) member advisory , Senior Citizens Immunization program for the LGUs, 2023 – up to present Phil Council for Health Research Development (PCHRD) Technical Review Committee member, 2014 up to present Healthway Philippines Inc. Medical Advisory Council member 2022- up to present Peer Reviewer : Acta Medica, JAMA

Asian Advisory Board /Working Grp membership:2022-up to present Asia Pacific Advisory Group of Experts on COVID Vaccine Effectiveness (AZ) Asia Pacific Advisory Group on Vaccination and Healthy Ageing Population and Prevention of RSV (Janssen) Asia Pacific Advisory Group on Pneumococcal Vaccination in adult and ageing population (MSD) Asia Pacific Advisory Group on Covid vaccination mRNA vaccine (Moderna) Asian Advisory Group on Dengue vaccine (Takeda)

Professional Awards/Recognitions 2023 PCP Presidential Award 2023 COVID-19 Hero Award , given by Manilamed Medical Center Manila 2023 20 Years Service Award University of the East Ramon Magsaysay Memorial Medical Center “ in recognition for dedicated , devoted, and valuable service “ to the Medical Center 2022 Presidential Award given by President R Duterte in Malacañang as member of the DOST Vaccine Expert Panel 2022 DOST Science for the People Award as member of the Vaccine Expert Panel 2022 Most Outstanding Cebu Institute of Medicine Alumnus , testament of honor and recognition “Physician with a Heart (Healer, Executive, Advocate, Researcher, Teacher) given 3th day of December 2022 Keynote speaker 61st CIM Commencement Exercises, July 27, 2023 2022 PCP Presidential Award citation as member Board of Regents 2022 IATF Recognition as member of the DOST Vaccine Expert Panel 2022 DOH Recognition as member of the DOST Vaccine Expert Panel 2022 DOH Recognition as awardee of the Gawad Bayaning Kalusugan 2020 2020 Phil Society for Microbiology and Infectious Diseases (PSMID) Gold Pioneer Award for Sustainability and Resilience of the Society 2020 Gawad Bayaning Kalusugan Award “In recognition to his service to the Filipino people during the Covid-19 pandemic” 2020 Philippine College of Physicians (PCP) Presidential Award Physicians Caring for the Philippines 2019 Philippine College of Physicians Distinguished Healthcare Advocacy Exemplar award In recognition of his work promoting adult vaccination, HIV prevention and care, and TB clinical management 2018 , granted by the Infectious Disease Society of America (IDSA) Fellow status in recognition of the “leadership in their institutions, their communities, and in the field of infectious diseases.” 2019 UP-PGH Medicine Alumni Association Oblation Leadership Award In recognition and appreciation of his leadership and dedication in the field of Medicine 2011 and 2012 Phil Society for Microbiology and Infectious Diseases (PSMID) Special Award for Exceptional Performance In recognition of his admirable efforts and extraordinary dedication as President of PSMID in the advancement of the Society’s mission and vision

Past Positions and Designations in National and International organizations:

Philippine Society for Microbiology and Infectious Diseases Co-chair of the technical working group of the Philippine Clinical Practice Guideline in the Diagnosis, Treatment and Prevention of Sexually Transmitted Diseases Adviser, Technical Working Group Clinical Practice Guideline in the Diagnosis Treatment and Prevention of Community Acquired Pneumonia Senior Advisory member to the technical working group of the Adult Immunization guideline Senior advisor to the HIV Working group (HWG) Clinical Practice guidelines on the Prevention, Diagnosis and treatment of Opportunistic infections in Human Immunodeficiency virus-infected adults and adolescents in the Philippines Co-chair of the technical working group of the Philippine Clinical Practice Guideline of Immunization for People Living with HIV PSMID representative to the Technical Working group of the Philippine Clinical Practice Guideline of Hepatitis B of the Hepatology Society of the Philippines (HSP) PSMID representative to the Technical Working group of the Philippine Clinical Practice Guideline of Hepatitis C of the Hepatology Society of the Philippines (HSP) Member, TWG of Healthcare Immunization Guideline for Filipinos 2011 Chairman , Specialty Board of Examiners 2011 and 2012

Technical Review Committee member, Phil Council for Health Research Development (PCHRD) 2014 up to present Technical Review consultant, Phil-UK Newton Research grant 2016 Philippine Coalition against Tuberculosis (PhilCAT) Board2010-2016 Department of Health Dengue vaccine advisory group of expert 2016 Department of Health Senior Citizens Immunization Program advisory group (2015-16) Department of Health National Adverse Event Following Immunization (NAEF) , Dengue vaccine school-based program, 2016 2014 Hepatology Society of the Philippines Hepatitis B guideline Viral Hepatitis Prevention and Control Program 2016 Member, Asian Advisory Board of the Community Acquired Pneumonia Immunization Trial in Adult (CAPITA study)2015 Member, Asia Pacific Expert Input Forum Pneumococcal vaccine (2016) MEDSCAPE, Steering Committee Faculty Member on Global Pneumococcal Disease Education , 2012-2018 Member, Global Pneumococcal Vaccine Expert Advisory 2019-2020 AZ COVID-19 International Vaccine Virtual Advisory Board ​2022 Moderna COVID-19 Vaccine Philippine Advisory Board 2022 Janssen Asia-Pacific Regional Advisory Board on Healthy Ageing 2022 Department of Health Co-chair, Technical Working group (TWG) Philippine Framework for Hospital Facility Development Program in Infectious Diseases 2019 up to present Department of Health Dengue TWG Clinical Management 2017-2019 Global Advisory member on Pneumococcal vaccine (MSD) 2019 Asia Pacific Advisory on Pneumococcal Vaccine MSD (2020- present) Philippine Advisory on Pneumococcal Vaccine (2017-present) PhilHealth Advisory Board on COVID Case Rate Reimbursement (2021-present) Clinical TrialData Safety Monitoring Board member, phase III, multicenter, observer blind, randomized, controlled study to evaluate immune equivalence of multi- dose formulation against single-dose formulation of Vi-DT Typhoid conjugate vaccine and safety in healthy Filipino participants aged 6 months to 45 years , Feb 2020 -Feb 2022 Dengvaxia coadministration with Adacel (Tdap), placebo controlled trial 2016-2017

Peer-reviewed Publications: (Arranged from latest to oldest) Alberto Chua, MD,1 Lynn Gomez, MD,2 Rontgene Solante, MD,3 Kay Beltran, MD,1 Eric Chua, MD,4 Renz Pasilan, MD,2 Erika Chan, MD,1 Nica Lee, MD,4 Ann Celestyn Uichanco, MD,3 Micaela San Diego, MD,4 and Abegail Danasen, MD4 Evaluation of Urine L-FABP Point of Care Kit in the Philippines as Predictive Marker of Clinical Severity of COVID-19 (EPOCH COVID study) . The PHILIPPINE JOURNAL OF INTERNAL MEDICINE publication of the Philippine College of Physicians Volume 60 Number 4 Oct – Dec 2022 Michael Woodward1 , *, Venkatasubramanian Ramasubramanian2 , Adeeba Kamarulzaman3 ,Terapong Tantawichien4 , Minggui Wang 5 , Joon Young Song6 , Won Suk Choi7 , Samsuridjal Djauzi8 , Rontgene Solante9 , Wen-Sen Lee1 0 , Kazuhiko Tateda 1 1 , HongXing Pan1 2 , Ning-Chi Wang13 , Tikki Pang 14. Addressing Unmet Needs in Vaccination for Older Adults in the Asia Pacific: Insights from the COVID-19 Pandemic . Clinical Interventions in Aging 2023:18 869–880 Sunate Chuenkitmongkol, Rontgene Solante, Erlina Burhan, Suwat Chariyalertsak, Nan-Chang Chiu, Dung Do-Van, Masliyana Husin, Kao-Pin Hwang, Sasisopin Kiertiburanakul, Prasad S. Kulkarni, Ping-Ing Lee, Rommel Crisenio Lobo, Cao Huu Nghia, Anna Ong-Lim, Sheamini Sivasampu, Jing Lian Suah, Peter Seah Keng Tok, Guy Thwaites & SEA Vaccine Effectiveness Expert Working Group (2022): Expert review on global real-world vaccine effectiveness against SARS-CoV-2, Expert Review of Vaccines, DOI: 10.1080/14760584.2022.2092472

Rontgene Solante, Carlos Alvarez-Moreno , Erlina Burhan , Suwat Chariyalertsak, Nan- Chang Chiu , Sunate Chuenkitmongkol, Dung Do-Van , Kao-Pin Hwang , Sasisopin Kiertiburanakul, Ping-Ing Lee , Rommel Crisenio Lobo , Alejandro Macias , Cao Huu Nghia, Anna Ong-Lim, Javier Ortiz Ibarra, Rosana Richtmann, Alfonso J. Rodriguez- Morales, Marco Aurélio P Safadi, and Hindra Irawan Satari. Further implications on the global real-world vaccine effectiveness against SARS-CoV-2 EXPERT REVIEW OF , AHEAD-OF-PRINT, 1-3 https://doi.org/10.1080/14760584.2022.2110073

Chuenkitmongkol S, Solante R, Burhan E, et al. Expert Review of Global Real-World Vaccine Effectiveness Against SARS-CoV-2, 20 June 2022, [Preprint version 3] Available at Research Square. https://doi.org/10.21203/rs.3.rs-1575499/v3 [Last accessed: June 2022]

Edsel Maurice T. Salvaña , Niña Theresa Dungca , Geraldine Arevalo, Kingbherly Li, Christian Francisco, Christine Penalosa, Angelo dela Tonga, Katerina Leyritana, Rontgene Solante, Rosario Jessica Tactacan-Abrenica, Jodor Lim, Marissa Alejandria, Noel Palaypayon, Brian Schwem. HIV-1 Subtype Shift in the Philippines is Associated With High Transmitted Drug Resistance, High Viral Loads, and Fast Immunologic Decline. International Journal of Infectious Diseases 122 (2022) 936–943

Epidemiological and clinical characteristics of the first 500 confirmed COVID-19 inpatients in a tertiary infectious disease referral hospital in Manila, Philippines . Kristal An Agrupis, Chris Smith , Shuichi Suzuki, Annavi Marie Villanueva, Koya Ariyoshi, Rontgene Solante, Elizabeth Freda Telan, Kelly Anne Estrada, Ann Celestyn Uichanco, Jocelyn Sagurit, Joy Calayo, Dorcas Umipig, Zita dela Merced, Fe Villarama, Efren Dimaano, Jose Benito Villarama, Edmundo Lopez and Ana Ria Sayo . Tropical Medicine and Health (2021) 49:48 https://doi.org/10.1186/s41182-021-00340-0

A. Ria Sayo, E. Grace M. Balinas, J.A. Verona, A. Marie G. Villanueva, S. Myat Han, J. Suzuki, K. Ariyoshi, C. Smith, R.M. Solante, COVID-19 screening on a tuberculosis ward in Manila, the Philippines, Journal of Clinical Tuberculosis and Other Mycobacterial Diseases (2020), doi: https://doi.org/ 10.1016/j.jctube.2020.100167

First COVID-19 infections in the Philippines: a case report . Edna M. Edrada1, Edmundo B. Lopez, Jose Benito Villarama, Eumelia P. Salva Villarama, Bren F. Dagoc,Chris Smith, Ana Ria Sayo, Jeffrey A. Verona, Jamie Trifalgar-Arches, Jezreel Lazaro, Ellen Grace M. Balinas, Elizabeth Freda O. Telan, Lynsil Roy, Myvie Galon, Carl Hill N. Florida, Tatsuya Ukawa, Annavi Marie G. Villaneuva, Nobuo Saito, Jean Raphael Nepomuceno, Koya Ariyoshi, Celia Carlos, Amalea Dulcene Nicolasora and Rontgene M. Solante. Tropical Medicine and Health (2020) 48:21 https://doi.org/10.1186/s41182-020-00203-0

Edsel Maurice T. Salvana, Genesis May J. Samonte, Elizabeth Telan, Katerina Leyritana, Rosario Jessica Tactacan-Abrenica, Patrick R. Ching, Geraldine M. Arevalo, Nin ̃a Theresa Dungca, Christine Pen ̃alosa-Ramos, Kevin Anthony R. Mendoza, Lyka F. Trinidad, Angelo dela Tonga, Jodor Lim, Raul Destura, Marissa Alejandria, Rontgene Solante, Lalaine Arcangel, Noel S. Palaypayon, Brian E. Schwem . High rates of tenofovir failure in a CRF01 AE-predominant HIV epidemic in the Philippines . International Journal of Infectious Diseases(2020). https://doi.org/10.1016/j.ijid.2020.02.020

Annavi Marie G. Villanueva, Jezreel Lazaro, Ana Ria Sayo, Su Myat Han,Tatsuya Ukawa, Shuichi Suzuki, Saho Takaya, Elizabeth Telan, Rontgene Solante, Koya Ariyoshi, and Chris Smith. COVID-19 Screening for Healthcare Workers in a Tertiary Infectious Diseases Referral Hospital in Manila, the Philippines . Am. J. Trop. Med. Hyg., 00(0), 2020, pp. 1–4doi:10.4269/ajtmh.20-0715

Nobuo Saito,Virginia O. Dimapilis, Hiroshi Fujii, Motoi Suzuki, Elizabeth Freda O. Telan, Dorcas Valencia Umipig, Rontgene M. Solante, Alexis Q. Dimapilis, Ferdinand De Guzman, Eumelia P. Salva, Fumihito Nakayama, Kohei Toda, Chris Smith, Koya Ariyoshi, and Christopher M. Parry . Diphtheria in Metro Manila, the Philippines 2006–2017: A Clinical, Molecular, and Spatial Characterization. Clinical Infectious Diseases 2020;XX(XX):1–8

If Not COVID-19 What Is It? Analysis of COVID-19 versus Common Respiratory Viruses among Symptomatic Health Care Workers in a Tertiary Infectious Disease Referral Hospital in Manila, Philippines . Kristal An Agrupis , Annavi Marie G. Villanueva , Ana Ria Sayo , Jezreel Lazaro , Su Myat Han , Alyannah C. Celis , Shuichi Suzuki , Ann Celestyn Uichanco , Jocelyn Sagurit , Rontgene Solante , Lay-Myint Yoshida , Koya Ariyoshi and Chris Smith. Tropical Medicine and Health (2020) 48:21 https://doi.org/10.1186/s41182-020-00203-0

Chien-Chang Lee , Apisarnthanarak, Anucha, Feng, Jia-Yih, Solante, Rontgene, Schuetz, Philipp. Procalcitonin (PCT)-guided antibiotic stewardship in Asia-Pacific countries: adaptation based on an expert consensus meeting. November 2020 Clinical Chemistry and Laboratory Medicine DOI:10.1515/cclm-2020-1724

Chien-Chang Lee, Andrea Lay Hoon Kwa, Anucha Apisarnthanarak, Jia-Yih Feng, Eric Howard Gluck, Akihiro Ito, Anis Karuniawati, Petrick Periyasamy, Busadee Pratumvinit, Jeetendra Sharma, Rontgene Solante, Subramanian Swaminathan, Niraj Tyagi, Dien Minh Vu, Kapil Zirpe and Philipp Schuetz* Procalcitonin (PCT)-guided antibiotic stewardship in Asia-Pacific countries: adaptation based on an expert consensus meeting. Clin Chem Lab Med 2020 . https://doi.org/10.1515/cclm-2019-1122

Yasuda I, Saito N, Suzuki M, Umipig DV, Solante RM, Guzman FD, et al. (2021) Unique characteristics of new complete blood count parameters, the Immature Platelet Fraction and the Immature Platelet Fraction Count, in dengue patients. PLoS ONE 16(11): e0258936. https://doi. org/10.1371/journal.pone.0258936

Shirley T. Padilla , Toshiro Niki , Daisuke Furushima , Gaowa Bai , Haorile Chagan-Yasutan , Elizabeth Freda Telan , Rosario Jessica Tactacan-Abrenica , Yosuke Maeda , Rontgene Solante and Toshio Hattori . Plasma Levels of a Cleaved Form of Galectin-9 Are the Most Sensitive Biomarkers of Acquired Immune Deficiency Syndrome and Tuberculosis Coinfection . Biomolecules 2020, 10, 1495; doi:10.3390/biom10111495

Nina Theresa Dungca, MSc; Brian Schwem, PhD; Geraldine Arevalo, BS; Christian Francisco, MD; Christine Penalosa-Ramos, MD; Patrick Ching, MD; Katerina Leyritana, MD; Raul Destura, MD; Jodor Lim, MD; Rosario Tactacan-Abrenica, MD; Elizabeth Telan, MD; Rontgene Solante, MD, FIDSA; Genesis Samonte, MD; Lyka Trinidad, RN; Kevin Mendoza, RN; Marissa M. Alejandria, MD, MSc; Edsel Maurice T. Salvana, MD, DTM&H, FIDSA Transmitted and Acquired NNRTI Resistance in the Philippines: Are Newer Generation NNRTIs a Viable Option. Open Forum Infectious Diseases 6(Supplement_2):S870-S870DOI:10.1093/ofid/ofz360.2185

Saito N, Takamura N, Retuerma GP, Frayco CH, Solano PS, Ubas CD, Lintag AV, Ribo MR, Solante RM, Dimapilis AQ, Telan EO, Go WS, Suzuki M, Ariyoshi K, Parry CM. Frequent Community Use of Antibiotics among a Low-Economic Status Population in Manila, the Philippines: A Prospective Assessment Using a Urine Antibiotic Bioassay. Am J Trop Med Hyg. 2018 Mar 5. doi: 10.4269/ajtmh.17-0564. [Epub ahead of print]

Salvana EM, Solante R. HIV in the Filipino healthcare worker: A way forward. Acta Med Philipp 2015; 49:1-3.

Agdamag DM, Kageyama S, Leaño PS, Solante RM, Telan EF, Que ER, Ichimura H. Prediction of response to treatment of chronic hepatitis B with pegylated interferon in the Philippines. J Med Virol. 2010 Feb;82(2):213-9.

Agdamag DM, Kageyama S, Alesna ET, Solante RM, Leaño PS, Heredia AM, Abellanosa-Tac-An IP, Vibal ET, Jereza LD, Ichimura H. Rapid spread of hepatitis C virus among injecting-drug users in the Philippines: Implications for HIV epidemics. J Med Virol. 2005 Oct;77(2):221-6.

Agdamag DM, Kageyama S, Solante R, Espantaleon AS, Sangco JC, Suzuki Y. Characterization of clinical isolates of Mycobacterium tuberculosis resistant to drugs and detection of RpoB mutation in multidrug-resistant tuberculosis in the Philippines. Int J Tuberc Lung Dis. 2003 Nov;7(11):1104-8. Ong-Tantuco, Marilou Solante, Rontgene, Torres, TessaEffect of Video in Improving Sterility in Blood Culture Collection. Phil J Microbiol Infect Dis 1997; 26(3):103-108 Resource Speaker of the following topics in Symposiums, Conventions, PostGraduate Courses and Round Table Discussions (both local and foreign ): Covid-19 Clinical management Vaccines Tuberculosis/ Multi-drug Resistant TB Clinical Management Adverse Drug Reaction Private- Pubic Mix DOTS HIV/AIDS Prevalence and Epidemiology Opportunistic Infections in HIV Role of Anti-retroviral agents Diagnosis and Management Molecular Diagnosis

∙ Sexually Transmitted Infections/Urinary Tract Infections Spectrum of Infections Diagnosis and Management, Resistance Patterns Immunologic Dilemma of Syphilis Serology Molecular Diagnosis of STIs Antimicrobial Stewardship ∙ Infections in the Immunocompromised Host ∙ Pneumonias Community Acquired/ Hospital Acquired Pneumonia Pneumonia in the Immunocompromised Atyical Pneumonia ∙ Hepatitis B and C ∙ Infection Control – Basic Infection Control Principles in the Usage of Antibiotics Molecular Diagnosis in Infectious Diseases Infections in the immunocompromised Adult Immunization Procalcitonin in Sepsis Utility of IGRA (QuantiFERON®-TB Gold) in the Philippines

KOL, Speaker and advisory group member: Pfizer, Regional and local anti-infective and vaccines MSD , Regional and local anti-infective and vaccines Sanofi Pasteur Vaccines Biomerieux Diagnostics Cathay Drug Anti-infective Westmont Unilab anti-infective Roche Philippines Diagnostics

EDUCATION/TRAININGS/ EXPERIENCES: LOCAL:

1. Primary and Secondary Education: Cebu State College

2. Bachelor of Science in Medical Technology Cebu Velez College, 1985

3. Doctor of Medicine: Cebu Institute of Medicine, 1989

Residency Training in Internal Medicine Metro Cebu Community Hospital, Cebu City January 1992-December 1994

Post- Residency Subspecialty Fellowship Training in Infectious Diseases University of the Philippines- Philippine General Hospital (UP-PGH) / Research Institute of Tropical Medicine (RITM) December 1994 – December 1996

b. FOREIGN trainings:

1. Diagnosis and Management of Tuberculosis and other Opportunistic Infections in HIV / AIDS - Molecular diagnosis of TB, HIV and other opportunistic infections - Clinical management of HIV/AIDS and TB with HIV Osaka National Hospital HIV/AIDS Clinical Laboratory, Osaka, Japan AIDS Clinical Center, Tokyo, Japan November 1998 - May 1999

2. Principles in STD/HIV Research and Management University of Washington, July 1-21, 2000 Seattle, Washington

Clinical Exposure, Counseling and Laboratory Diagnosis HIV/AIDS Bamrasnadura Hospital, November 1-30 1999 Bangkok, Thailand

EXAMINATIONS PASSED: Government Civil Service Examination (Subprofessional/Professional) 1982 and 1985 Medical Technology Licensure Board Examination, September 1990 Physician Licensure Examination, August 1990 Diplomate Examination, Philippine Board of Internal Medicine-Philippine College of Physicians 1997 Diplomate Examination, Philippine Society for Microbiology and Infectious Diseases, 1999 (ranked 1st)